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Chemical Structure| 612530-44-6 Chemical Structure| 612530-44-6

Structure of PTP1B-IN-1
CAS No.: 612530-44-6

Chemical Structure| 612530-44-6

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PTP1B-IN-1 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 1.6 mM.

Synonyms: PTP1B inhibitor

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of PTP1B-IN-1

CAS No. :612530-44-6
Formula : C8H8N2O3S
M.W : 212.23
SMILES Code : O=S(N1C2=CC=CC=C2)(NC(C1)=O)=O
Synonyms :
PTP1B inhibitor
English Name :5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide
MDL No. :MFCD18206847
InChI Key :LDCZCUKQWRZSDT-UHFFFAOYSA-N
Pubchem ID :4369452

Safety of PTP1B-IN-1

Related Pathways of PTP1B-IN-1

pyroptosis

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Male Sprague-Dawley rats Spared nerve injury (SNI) model Intrathecal injection 0.1, 0.5, or 1 μg PTP1B-IN-1 Once daily for 5 consecutive days To evaluate the alleviating effect of PTP1B-IN-1 on SNI-induced neuropathic pain, results showed PTP1B-IN-1 significantly reversed mechanical allodynia and suppressed ER stress, NF-κB activation, and neuroinflammation. CNS Neurosci Ther. 2024 Feb;30(2):e14609

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.71mL

0.94mL

0.47mL

23.56mL

4.71mL

2.36mL

47.12mL

9.42mL

4.71mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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