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Chemical Structure| 592542-59-1 Chemical Structure| 592542-59-1

Structure of Rigosertib
CAS No.: 592542-59-1

Chemical Structure| 592542-59-1

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Rigosertib is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM and shows 30-fold greater selectivity against PLK2 and no activity to PLK3.

Synonyms: ON-01910

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Rigosertib

CAS No. :592542-59-1
Formula : C21H25NO8S
M.W : 451.49
SMILES Code : O=S(/C=C/C(C(OC)=C1)=C(OC)C=C1OC)(CC2=CC=C(OC)C(NCC(O)=O)=C2)=O
Synonyms :
ON-01910
English Name :(E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetic acid
MDL No. :MFCD09038489
InChI Key :OWBFCJROIKNMGD-BQYQJAHWSA-N
Pubchem ID :6918736

Safety of Rigosertib

Related Pathways of Rigosertib

RTK
PI3K-AKT
Hedgehog

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.07mL

2.21mL

1.11mL

22.15mL

4.43mL

2.21mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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