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Chemical Structure| 14113-05-4 Chemical Structure| 14113-05-4

Structure of Royal Jelly acid
CAS No.: 14113-05-4

Chemical Structure| 14113-05-4

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Royal jelly acid is a naturally occuring unsaturated fatty acid found in royal jelly which can suppress both VEGF-induced human umbilical vein endothelial cells (HUVECs) proliferation and migration, and possesses effect on cholesterol-lowering, antiinflammatory, wound-healing and antibiotic.

Synonyms: Queen Bee Acid; 10-Hydroxy-2-(E)-decenoic acid; 10-HDA

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Royal Jelly acid

CAS No. :14113-05-4
Formula : C10H18O3
M.W : 186.25
SMILES Code : O=C(O)/C=C/CCCCCCCO
Synonyms :
Queen Bee Acid; 10-Hydroxy-2-(E)-decenoic acid; 10-HDA
English Name :(E)-10-Hydroxydec-2-enoic acid
MDL No. :MFCD00204506
InChI Key :QHBZHVUGQROELI-SOFGYWHQSA-N
Pubchem ID :5312738

Safety of Royal Jelly acid

Related Pathways of Royal Jelly acid

RTK
pyroptosis

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Hippocampal neurons 0–30 µM 48 hours QBA inhibited glutamate-induced neuronal death with an IC50 of 56.0±27.3 nM and increased mitochondrial health with an EC50 of 317.5±200.3 nM. Nutrients. 2017 Dec 23;10(1):13
Hippocampal neurons 0–30 µM 48 hours QBA reduced hypoxia-induced neuronal death with an IC50 of 64.6±17.9 nM and increased mitochondrial health with an EC50 of 156.9±58.4 nM. Nutrients. 2017 Dec 23;10(1):13
Hippocampal neurons 0–30 µM 7 days QBA increased the growth of hippocampal neurons with an EC50 of 75.9±29.1 nM, and maximal growth occurred between 0.3–30 μM. Nutrients. 2017 Dec 23;10(1):13

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Sprague-Dawley rats Aged rats Oral 12–24 mg/kg/day 3.5 months QBA reduced anxiety-like behavior, increased body weight, and better maintained body weight during behavioral testing. Nutrients. 2017 Dec 23;10(1):13

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.37mL

1.07mL

0.54mL

26.85mL

5.37mL

2.68mL

53.69mL

10.74mL

5.37mL

References

 

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