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Chemical Structure| 158876-82-5 Chemical Structure| 158876-82-5

Structure of Rupatadine
CAS No.: 158876-82-5

Chemical Structure| 158876-82-5

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Rupatadine is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 μM (rabbit platelet membranes/guinea pig cerebellum membranes).

Synonyms: UR-12592

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Product Details of Rupatadine

CAS No. :158876-82-5
Formula : C26H26ClN3
M.W : 415.96
SMILES Code : CC1=CN=CC(CN2CC/C(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C5\3)=C1
Synonyms :
UR-12592
MDL No. :MFCD09039284
InChI Key :WUZYKBABMWJHDL-UHFFFAOYSA-N
Pubchem ID :133017

Safety of Rupatadine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H413
Precautionary Statements:P301+P312+P330

Related Pathways of Rupatadine

GPCR

Isoform Comparison

Biological Activity

Description
Rupatadine (UR-12592) is a highly potent, orally active, and long-lasting dual antagonist of PAF and H1 receptors, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine is applicable in the study of allergic rhinitis and urticaria[1][2][3].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03770923 Rheumatoid Arthritis Phase 3 Recruiting October 2027 Egypt ... More >> Sherief Abd-Elsalam Recruiting Tanta, Egypt, 35111 Contact: Fedaa Kotkata, Msc Less <<
NCT01481909 Mastocytosis Phase 2 Phase 3 Completed - Germany ... More >> University Charité Berlin, Germany, 10117 Less <<
NCT00162786 Healthy Phase 4 Terminated - Netherlands ... More >> Brain and Behaviour Institute Maastricht, Netherlands, 6229 ET Less <<
NCT00258141 Allergy Phase 4 Unknown - Finland ... More >> Ulappatorin Lääkäriasema Not yet recruiting Espoo, Finland Principal Investigator: Leena Ackermann, MD          Koskiklinikka, Tampere Lääkärikeskus Not yet recruiting Tampere, Finland, 33101 Principal Investigator: Ari Karppinen, MD Less <<
NCT00199225 Human Experimentation (Human V... More >>olunteers) Less << Phase 1 Completed - Spain ... More >> Centre de Investigació de Medicaments-Intitut de Recerca-Hospital de la Santa Creu i Sant Pau Barcelona, Spain, 08025 Less <<
NCT01605487 Cold Contact Urticaria Phase 2 Completed - Germany ... More >> Department of Dermatology and Allergy Charité - Universitätsmedizin Berlin, Charitéplatz 1, Germany, 10117 Berlin Less <<
NCT00199251 Urticaria Phase 3 Terminated - -
NCT02358265 Chronic Urticaria Phase 3 Unknown June 2017 Germany ... More >> Allergie-Centrum-Charite Recruiting Berlin, Germany, 10117 Contact: Karsten Weller, MD       karsten.weller@charite.de    Contact: Marcus Maurer, MD       marcus.maurer@charite.de    Principal Investigator: Karsten Weller, MD Less <<
NCT00199238 Urticaria Phase 2 Terminated - France ... More >> Hospital Saint Louis Paris Cedex 10, France, 75475 Less <<
NCT05356143 Healthy PHASE1 COMPLETED 2023-01-05 Pharma Medica Research Inc., T... More >>oronto, Ontario, M1S 3V6, Canada Less <<
NCT06708520 Renal Impairment PHASE1 RECRUITING 2025-12-24 Centro Hospitalar De Vila Nova... More >> De Gaia Espinho, Gaia, 4434-502, Portugal|Hospital Pedro Hispano, Matosinhos, 4450-113, Portugal|Blueclinical Investigacao E Desenvolvimento Em Saude Lda., Porto, 4250-449, Portugal|Hospital Universitari Germans Trias I Pujol, Badalona, 8916, Spain|Municipal Institute Of Medical Investigation, Barcelona, 08003, Spain|Hospital De La Santa Creu I Sant Pau, Barcelona, 08025, Spain|Hospital Universitario De La Princesa, Madrid, 28006, Spain Less <<
NCT06736340 Hepatic Impairment PHASE1 RECRUITING 2025-12-24 Centro Hospitalar De Vila Nova... More >> De Gaia Espinho, Gaia, 4434-502, Portugal|Hospital Pedro Hispano, Matosinhos, 4450-113, Portugal|BlueClinical Phase I, Porto, 4250-449, Portugal|Municipal Institute Of Medical Investigation, Barcelona, 08003, Spain|Hospital Universitario De La Princesa, Madrid, 28006, Spain|Hospital Clinico San Carlos, Madrid, 28040, Spain|Hospital Universitario La Paz, Madrid, 28046, Spain Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

12.02mL

2.40mL

1.20mL

24.04mL

4.81mL

2.40mL

References

 

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