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Chemical Structure| 2262489-89-2 Chemical Structure| 2262489-89-2

Structure of S2116
CAS No.: 2262489-89-2

Chemical Structure| 2262489-89-2

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S2116, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2116 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2116 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2116 significantly retardes the growth of T-ALL cells in xenotransplanted mice[1].

Synonyms: S2116

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Product Details of S2116

CAS No. :2262489-89-2
Formula : C22H26ClF2N3O2
M.W : 437.91
SMILES Code : FC1=CC(F)=C(OCC2=CC=CC=C2)C([C@H]3[C@H](NCC(N4C[C@@H](N)CC4)=O)C3)=C1.[H]Cl
Synonyms :
S2116

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2.28mL

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