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Chemical Structure| 2262488-39-9 Chemical Structure| 2262488-39-9

Structure of S2157
CAS No.: 2262488-39-9

Chemical Structure| 2262488-39-9

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S2157, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2157 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood-brain barrier and can almost completely eradicate CNS leukemia in mice transplanted with T-ALL cells[1].

Synonyms: S2157

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Product Details of S2157

CAS No. :2262488-39-9
Formula : C23H28ClF2N3O2
M.W : 451.94
SMILES Code : CN1CCN(C(CN[C@H]2[C@H](C3=CC(F)=CC(F)=C3OCC4=CC=CC=C4)C2)=O)CC1.[H]Cl
Synonyms :
S2157

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2.21mL

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