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Chemical Structure| 2458219-65-1 Chemical Structure| 2458219-65-1

Structure of SHP2-D26
CAS No.: 2458219-65-1

Chemical Structure| 2458219-65-1

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SHP2-D26 is a first, potent, and effective PROTAC degrader of SHP2 protein. SHP2-D26 achieves DC50 values of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, respectively, and is capable of reducing SHP2 protein levels by >95% in cancer cells. SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines.

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Product Details of SHP2-D26

CAS No. :2458219-65-1
Formula : C56H79ClN12O6S2
M.W : 1115.89
SMILES Code : C([C@@H](NC(CCCCCCCCN1CCN(C(CCC(NC2=C(Cl)C(SC=3C(N)=NC(=CN3)N4CCC(C)(N)CC4)=CC=C2)=O)=O)CC1)=O)[C@@](C)(C)C)(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C=7SC=NC7C)=O)C[C@@H](O)C5
MDL No. :N/A

Safety of SHP2-D26

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of SHP2-D26

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

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0.90mL

0.18mL

0.09mL

4.48mL

0.90mL

0.45mL

8.96mL

1.79mL

0.90mL

 

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