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Chemical Structure| 24418-86-8 Chemical Structure| 24418-86-8

Structure of SKI V
CAS No.: 24418-86-8

Chemical Structure| 24418-86-8

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for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2].

Synonyms: SKI V

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Product Details of SKI V

CAS No. :24418-86-8
Formula : C15H10O4
M.W : 254.24
SMILES Code : O=C1/C(OC2=CC=CC=C12)=C\C3=CC=C(O)C(O)=C3
Synonyms :
SKI V
MDL No. :MFCD07772193

Safety of SKI V

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P280-P264-P305+P351+P338-P337+P313

Related Pathways of SKI V

MAPK

Isoform Comparison

Biological Activity

Description
SKI V is a highly potent noncompetitive inhibitor of non-lipid sphingosine kinase (SPHK; SK), with an IC50 of 2 μM for GST-hSK. Additionally, SKI V exhibits potent inhibition of PI3K, with an IC50 of 6 μM for hPI3K. It effectively reduces the formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V demonstrates apoptotic induction and displays significant antitumor activity[1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.67mL

3.93mL

1.97mL

39.33mL

7.87mL

3.93mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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