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Chemical Structure| 2682114-54-9 Chemical Structure| 2682114-54-9

Structure of SP-96
CAS No.: 2682114-54-9

Chemical Structure| 2682114-54-9

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SP-96 is a highly selective and non-ATP-competitive Aurora A/B inhibitor with IC50 values of 0.316nM 18.975 nM for Aurora A and Aurora B, respectively.

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Product Details of SP-96

CAS No. :2682114-54-9
Formula : C25H20FN7O
M.W : 453.47
SMILES Code : FC1=CC(NC(NC2=CC(NC3=C(C=CC(C4=CN(C)N=C4)=C5)C5=NC=N3)=CC=C2)=O)=CC=C1
MDL No. :MFCD32858307
InChI Key :CGDYRZUPKPBLND-UHFFFAOYSA-N
Pubchem ID :154573766

Safety of SP-96

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H320-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of SP-96

epigenetics
DNA

Isoform Comparison

Biological Activity

Description
SP-96 is a potent, selective, and non-ATP-competitive inhibitor of Aurora B (IC50=0.316 nM), with >2000 fold selectivity against FLT3 and KIT. It demonstrates selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 is a valuable tool for researching triple negative breast cancer (TNBC)[1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

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10 mM

2.21mL

0.44mL

0.22mL

11.03mL

2.21mL

1.10mL

22.05mL

4.41mL

2.21mL

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