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Chemical Structure| 30675-13-9 Chemical Structure| 30675-13-9

Structure of TCID
CAS No.: 30675-13-9

Chemical Structure| 30675-13-9

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TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.

Synonyms: 4,5,6,7-Tetrachloroindan-1,3-dione; UCH-L3 Inhibitor

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of TCID

CAS No. :30675-13-9
Formula : C9H2Cl4O2
M.W : 283.92
SMILES Code : O=C1CC(C2=C1C(Cl)=C(Cl)C(Cl)=C2Cl)=O
Synonyms :
4,5,6,7-Tetrachloroindan-1,3-dione; UCH-L3 Inhibitor
English Name :4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione
MDL No. :MFCD00239209

Safety of TCID

Isoform Comparison

Biological Activity

Target
  • UCH

    UCH-L3, IC50:0.6 μM

In Vitro:

Cell Line
Concentration Treated Time Description References
MES GSCs (MES21, MES505) 10 μM TCID inhibits UCHL3 activity, leading to POLD4 degradation and reducing self-renewal capacity and radiation resistance in MES GSCs Cell Mol Life Sci. 2024 Jun 3;81(1):247.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Nude mice Orthotopic xenograft model Micro-osmotic pump infusion 10 mg/kg 0.5 μl/h for 7 days TCID significantly enhanced the therapeutic effect of radiation, reducing tumor growth and prolonging survival Cell Mol Life Sci. 2024 Jun 3;81(1):247.

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.61mL

3.52mL

1.76mL

35.22mL

7.04mL

3.52mL

References

 

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