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Chemical Structure| 2226941-26-8 Chemical Structure| 2226941-26-8

Structure of THK01
CAS No.: 2226941-26-8

Chemical Structure| 2226941-26-8

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THK01 is an efficient ROCK2 inhibitor with IC50 values of 5.7 nM (ROCK2) and 923 nM (ROCK1). It inhibits breast cancer metastasis through the ROCK2-STAT3 signaling pathway and is widely used in breast cancer research, especially in studies exploring tumor metastasis mechanisms.

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Product Details of THK01

CAS No. :2226941-26-8
Formula : C20H13N3O2
M.W : 327.33
SMILES Code : O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)NC6=C3C=C(O)C=C6
MDL No. :N/A

Safety of THK01

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P264-P270-P280-P301+P312+P330-P305+P351+P338-P337+P313-P501

Related Pathways of THK01

cytoskeleton

Isoform Comparison

Biological Activity

Description
THK01 serves as a potent ROCK2 inhibitor with IC50 values of 5.7 and 923 nM for ROCK2 and ROCK1, respectively. It inhibits breast cancer metastasis through the ROCK2-STAT3 signaling pathway and is useful for breast cancer research[1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.28mL

3.06mL

1.53mL

30.55mL

6.11mL

3.06mL

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