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Chemical Structure| 2935964-98-8 Chemical Structure| 2935964-98-8

Structure of TNG260
CAS No.: 2935964-98-8

Chemical Structure| 2935964-98-8

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TNG260 is a selective corepressor of CoREST (CoreDAC). It inhibits HDAC1 with 10 times the selectivity over HDAC3.

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of TNG260

CAS No. :2935964-98-8
Formula : C20H18FN3O2S
M.W : 383.44
SMILES Code : O=C(NC1=CC(C2=CC=C(F)C=C2)=CC=C1N)C3=CC=C([S@@](=N)(C)=O)C=C3
English Name :(R)-N-(4-Amino-4'-fluoro-[1,1'-biphenyl]-3-yl)-4-(S-methylsulfonimidoyl)benzamide
MDL No. :N/A

Safety of TNG260

Related Pathways of TNG260

epigenetics

Isoform Comparison

Biological Activity

Description
TNG260 is a CoREST-selective deacetylase (CoreDAC) inhibitor, which inhibits HDAC1 with 10-fold selectivity over HDAC3. By targeting HDAC1, TNG260 not only counters anti-PD1 resistance associated with the loss of STK11 but also reduces the infiltration of neutrophils within tumors and promotes immune-mediated cell death[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.04mL

2.61mL

1.30mL

26.08mL

5.22mL

2.61mL

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