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Chemical Structure| 1310693-92-5 Chemical Structure| 1310693-92-5

Structure of Tubastatin A HCl
CAS No.: 1310693-92-5

Chemical Structure| 1310693-92-5

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Tubastatin A Hydrochloride (Tubastatin A HCl) is a potent and selective HDAC6 inhibitor with an IC50 of 15 nM in a cell-free assay. It is 1000-fold more selective against all other isozymes except HDAC8, which it inhibits 57-fold more selectively. Tubastatin A Hydrochloride also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).

Synonyms: TSA HCl; Tubastatin A Hydrochloride

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Product Details of Tubastatin A HCl

CAS No. :1310693-92-5
Formula : C20H22ClN3O2
M.W : 371.86
SMILES Code : O=C(NO)C1=CC=C(CN2C3=C(CN(C)CC3)C4=C2C=CC=C4)C=C1.[H]Cl
Synonyms :
TSA HCl; Tubastatin A Hydrochloride
MDL No. :MFCD20488052
InChI Key :LJTSJTWIMOGKRJ-UHFFFAOYSA-N
Pubchem ID :57336514

Safety of Tubastatin A HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Tubastatin A HCl

epigenetics

Isoform Comparison

Biological Activity

Target
  • HDAC8

    HDAC8, IC50:854 nM

  • HDAC6

    HDAC6, IC50:15 nM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.45mL

2.69mL

1.34mL

26.89mL

5.38mL

2.69mL

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