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Chemical Structure| 1612782-86-1 Chemical Structure| 1612782-86-1

Structure of UNC2541
CAS No.: 1612782-86-1

Chemical Structure| 1612782-86-1

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UNC2541 is a specific MerTK inhibitor with high affinity for the MerTK ATP binding pocket. It has potential applications in inhibiting phosphorylated MerTK and related cancer research.

4.5 *For Research Use Only !

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Product Details of UNC2541

CAS No. :1612782-86-1
Formula : C24H34FN7O2
M.W : 471.57
SMILES Code : N[C@@H]1C(NCCCCCC/N=C2N=CC(C(NCC3=CC=C(F)C=C3)=O)=C(N/2)NCCCC1)=O
MDL No. :MFCD32174280

Safety of UNC2541

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of UNC2541

RTK

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Bone marrow-derived macrophages (BMDM) 2.5 µM 30 minutes UNC2541 significantly abolished the pro-phagocytic effect of ozone and inhibited the engulfment of apoptotic neutrophils by BMDMs. Front Immunol. 2024 Nov 19;15:1455771

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
ICR mice and C57BL/6 mice Chronic constriction injury (CCI) model Pretreatment around the sciatic nerve 25 mM Single pretreatment, lasting 30 minutes UNC2541 significantly abolished the analgesic effect of ozone in CCI mice. Front Immunol. 2024 Nov 19;15:1455771

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.12mL

0.42mL

0.21mL

10.60mL

2.12mL

1.06mL

21.21mL

4.24mL

2.12mL

 

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