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Chemical Structure| 899937-47-4 Chemical Structure| 899937-47-4

Structure of WRX606
CAS No.: 899937-47-4

Chemical Structure| 899937-47-4

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WRX606 is an inhibitor for mTOR complex 1 (mTORC1). WRX606 inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 S6K1, and the phosphorylation of the eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) in MCF-7. WRX606 exhibits cytotoxicity to HepG2 with IC50 of 17 nM. WRX606 exhibits antitumor efficacy in mouse models[1].

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of WRX606

CAS No. :899937-47-4
Formula : C28H25ClN4O6
M.W : 548.97
SMILES Code : O=C(NCC1=CC=C(OCO2)C2=C1)CCCN3C(N(CC(NC4=CC=CC(Cl)=C4)=O)C5=C(C=CC=C5)C3=O)=O
English Name :N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(1-(2-((3-chlorophenyl)amino)-2-oxoethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)butanamide
MDL No. :MFCD14737591

Safety of WRX606

Related Pathways of WRX606

PI3K-AKT

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1 mM

5 mM

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1.82mL

0.36mL

0.18mL

9.11mL

1.82mL

0.91mL

18.22mL

3.64mL

1.82mL

 

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