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Chemical Structure| 1311423-89-8 Chemical Structure| 1311423-89-8

Structure of YF-2
CAS No.: 1311423-89-8

Chemical Structure| 1311423-89-8

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YF-2 is a highly selective and blood-brain-barrier permeable histone acetyltransferase activator, it acetylates H3 in the hippocampus.

Synonyms: YF-2

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Product Details of YF-2

CAS No. :1311423-89-8
Formula : C20H22ClF3N2O3
M.W : 430.85
SMILES Code : O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C
Synonyms :
YF-2
MDL No. :MFCD22665763
InChI Key :TZHLDFAKTWDTOW-UHFFFAOYSA-N
Pubchem ID :53230697

Safety of YF-2

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of YF-2

epigenetics

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice 4T1-Luc lung metastasis model Intravenous injection 200 μM, 100 μl Single injection, observation time up to 180 minutes Visualize breast cancer lung metastasis, YF-2 showed stronger fluorescence signals in the lungs of metastatic mice than normal mice Sci Adv. 2025 Apr 4;11(14):eadr5541

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.60mL

2.32mL

1.16mL

23.21mL

4.64mL

2.32mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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