Home Chemistry Heterocyclic Building Blocks Piperidines 1,4'-Bipiperidine
Reduction: 1,4'-bipiperidine can be reduced to form 1,4-diaminobutane. This can be achieved using reducing agents like lithium aluminum hydride (LiAlH4) or catalytic hydrogenation.
Acylation: The nitrogen atoms in the piperidine rings can undergo acylation reactions, where an acyl group (R-C=O) is added. This can be achieved by treating 1,4'-bipiperidine with an acylating agent and a suitable catalyst.
Alkylation: The nitrogen atoms can also be alkylated, meaning that an alkyl group (R-CH2-) is introduced. This can be achieved by treating 1,4'-bipiperidine with an alkylating agent and a suitable catalyst.
Nucleophilic Substitution: The nitrogen atoms can act as nucleophiles in reactions with electrophiles. For example, they can react with alkyl halides or other electrophiles to form substituted products.
Ring Opening Reactions: The piperidine rings can undergo ring-opening reactions under certain conditions. This can lead to the formation of open-chain compounds.
Complexation Reactions: Due to the presence of nitrogen atoms, 1,4'-bipiperidine can form complexes with various metal ions. This can lead to the formation of coordination compounds with unique properties.
Oxidation Reactions: The nitrogen atoms can be oxidized under certain conditions, leading to the formation of various oxidation products.
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tert-butyl 4-(hydroxymethyl)-[1,4'-bipiperidine]-1'-carboxylate
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Ethyl1,4'-Bipiperidine-4-Carboxylate HCl
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tert-Butyl 4-amino-[1,4'-bipiperidine]-1'-carboxylate
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1-(Chlorocarbonyl)-4-(piperidin-1-yl)piperidine HCl
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1’-Boc-[1,4’-bipiperidine]-4-carboxylicAcid
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