Home Chemistry Heterocyclic Building Blocks Indazoles 1-Ethyl-1H-Indazole
Substitution Reactions: The indazole ring can undergo various substitution reactions, such as electrophilic aromatic substitution, nucleophilic aromatic substitution, or radical substitution, leading to the formation of substituted indazoles.
Alkylation: The nitrogen atom in the indazole ring can be alkylated by reaction with alkyl halides or sulfonates.
Acylation: The nitrogen atom in the indazole ring can undergo acylation reactions to form N-acyl derivatives.
Ring-closure Reactions: The nitrogen atom in the indazole ring can participate in ring-closure reactions, leading to the formation of cyclic compounds or fused-ring systems.
Oxidation: The electron-rich indazole ring can be oxidized to form various oxidation products under appropriate conditions.
Reduction: The electron-deficient indazole ring can be reduced to form various reduction products using reducing agents such as lithium aluminum hydride or sodium borohydride.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Protonation: The nitrogen atoms in the indazole ring can be protonated under acidic conditions to form the corresponding ammonium salts.
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