Home Chemistry Organic Building Blocks Iodides 1-Fluoro-2-Iodobenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —I,—F).
Sandmeyer Reaction: Iodobenzene can undergo a Sandmeyer reaction, where it is treated with a copper(I) salt and a source of nitrogen. This leads to the replacement of the iodine atom with a new functional group, such as an 【amine|https://www.ambeed.com/amines.html】, 【azide|https://www.ambeed.com/azides.html】, or 【cyanide|https://www.ambeed.com/nitriles.html】.
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
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1-Fluoro-3-(difluoromethyl)-2-iodobenzene
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