Home Chemistry Organic Building Blocks Fluorinated Building Blocks 1-Fluoro-3-Nitrobenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—NO2).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Sulfonation: Nitrobenzene can be sulfonated to introduce a sulfonic acid group (-SO3H) onto the benzene ring. Sulfonation is carried out using concentrated sulfuric acid, which leads to the substitution of one of the hydrogen atoms on the ring.
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1-Chloro-2-fluoro-5-methyl-4-nitrobenzene
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1-Fluoro-2-methoxy-5-methyl-3-nitrobenzene
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1-(Difluoromethoxy)-2-fluoro-4-nitrobenzene
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1-(5-Fluoro-2-hydroxy-3-nitrophenyl)ethanone
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