Home Chemistry Heterocyclic Building Blocks Indoles 1-Phenyl-1H-Indole
Electrophilic Aromatic Substitution (EAS): This is a common reaction for aromatic compounds like indoles. The phenyl group can undergo substitution reactions where an electrophile replaces a hydrogen atom. For example, Friedel-Crafts acylation or alkylation.
Nucleophilic Substitution: The nitrogen in the indole ring can potentially act as a nucleophile, especially under basic conditions.
Oxidation/Reduction Reactions: The indole ring system can be subject to oxidation or reduction reactions. For example, the oxidation of indoles can lead to the formation of oxindoles.
Arylation: The phenyl group itself can undergo reactions typical of aryl groups, such as coupling reactions in the presence of palladium catalysts.
Mannich Reaction: The indole nitrogen can potentially participate in a Mannich reaction, which involves the formation of a carbon-nitrogen bond.
Cyclization Reactions: Depending on the conditions and reagents used, 1-phenyl-1H-indole can undergo cyclization reactions to form other indole-derived compounds.
Hofmann Rearrangement: Under certain conditions, the indole nitrogen can undergo a rearrangement reaction.
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2-(Di-tert-butylphosphino)-1-phenyl-1H-indole
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1-(4-Fluorophenyl)-1H-indole-5-carboxylic acid
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