Home Chemistry Organic Building Blocks Fluorinated Building Blocks 2,6-Difluorobenzonitrile
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—C≡N).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Cyanation and Cyanation Reactions: The cyano group in benzonitrile can serve as a nucleophile in various reactions, leading to the introduction of cyano groups onto other molecules.
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3-Amino-4-bromo-2,6-difluorobenzonitrile
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4-(Difluoromethoxy)-2,6-difluorobenzonitrile
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(4-Cyano-3,5-difluorophenyl)boronic acid
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2,6-Difluoro-3-(trifluoromethyl)benzonitrile
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