Home Chemistry Heterocyclic Building Blocks Naphthyridines 2,7-Naphthyridine
Nucleophilic Substitution: Under appropriate conditions, 2,7-naphthyridine can undergo nucleophilic substitution reactions. For instance, it can react with strong nucleophiles like sodium amide (NaNH2) to introduce substituents at the nitrogen atom.
Reduction: 2,7-naphthyridine can be reduced to its dihydro derivative using reducing agents like hydrogen gas H2 and a catalyst (e.g., palladium on carbon, PtO2) to yield a saturated compound.
Halogenation: It can react with halogens (e.g., bromine, chlorine) to undergo halogenation reactions, typically under mild conditions.
Oxidation: 2,7-naphthyridine can be oxidized to various oxidation states using suitable oxidizing agents. For instance, it can be oxidized to the corresponding pyridine derivative.
Alkylation and Acylation: 2,7-naphthyridine can react with alkyl halides and acyl chlorides in the presence of appropriate bases to introduce alkyl or acyl groups onto the nitrogen atom or the ring.
Grignard Reaction: It can react with Grignard reagents to form new carbon-carbon bonds, allowing the introduction of various substituents onto the ring.
Ring Opening: Depending on the reaction conditions, it may undergo ring-opening reactions to produce open-chain compounds with appropriate reagents and catalysts.
Cyclization: It can participate in various cyclization reactions to form different heterocyclic compounds when combined with suitable reagents.
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6,8-Dichloro-2,7-naphthyridin-1(2H)-one
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