Chemistry Organic Building Blocks Ethers 2-Chloro-4-Fluoro-1-Methoxybenzene

2-Chloro-4-Fluoro-1-Methoxybenzene

These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—OCH3,—F).

Electrophilic Substitution Reactions: Chlorobenzene's electron-rich aromatic ring can undergo substitution reactions where a hydrogen atom is replaced by a chlorine atom. For instance, it can undergo nitration, sulfonation, and Friedel-Crafts alkylation/acylation reactions.
Aluminum Chloride Demethylation: Methoxybenzene can be demethylated using aluminum chloride (AlCl3) as a catalyst, leading to the formation of 【phenol|https://www.ambeed.com/phenols.html】 and methanol.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.

Further Reading:

Framework+−

(1S,4Ar,7Ar)-1-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-1,4A,5,7A-Tetrahydrocyclopenta[C]Pyran (2,2,2-Trifluoroethoxy)Benzene (2-(Benzyloxy)Phenyl)Boronic Acid (2-(Phenoxymethyl)Phenyl)Boronic Acid (2-Chloro-3-Methoxyphenyl)Boronic Acid (2-Chloroethoxy)Benzene (2-Methoxyethoxy)Benzene (3-(Benzyloxy)Phenyl)Boronic Acid (3-(Phenoxymethyl)Phenyl)Boronic Acid (3-Chloro-2-Methoxyphenyl)Boronic Acid (3-Phenoxyphenyl)Methanol (4-(Benzyloxy)Phenyl)Boronic Acid (4-(Phenoxymethyl)Phenyl)Boronic Acid (4-Methoxyphenyl)(Phenyl)Methanone (9H-Fluoren-9-Yl)Methyl (2-(Benzyloxy)Ethyl)Carbamate (9H-Fluoren-9-Yl)Methyl (4-Methoxybenzyl)Carbamate (Allyloxy)Benzene (Ethoxymethyl)Benzene (Hexyloxy)Benzene (Methoxymethyl)Benzene (Prop-2-Yn-1-Yloxy)Benzene (R)-2-Phenoxytetrahydro-2H-Pyran (S)-7-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-7,8,9,10-Tetrahydrotetracene-5,12-Dione 1,2-Bis(Benzyloxy)Benzene 1,2-Dichloro-3-Methoxybenzene 1,2-Dichloro-4-Methoxybenzene 1,2-Difluoro-3-Methoxybenzene 1,2-Difluoro-4-Methoxybenzene 1,2-Dimethoxybenzene 1,2-Diphenoxyethane 1,3-Bis(Benzyloxy)Benzene 1,3-Dibromo-2-Methoxybenzene 1,3-Dichloro-2-Methoxybenzene 1,3-Diiodo-2-Phenoxybenzene 1,3-Dimethoxybenzene 1,3-Diphenoxybenzene 1,4-Dichloro-2-Methoxybenzene 1,4-Dimethoxybenzene 1-(2-Methoxyphenyl)Ethan-1-One 1-(3-(Benzyloxy)Phenyl)Ethan-1-One 1-(3-Methoxyphenyl)Ethan-1-One 1-(3-Methoxyphenyl)Piperazine 1-(4-(Benzyloxy)Phenyl)Ethan-1-One 1-(4-Methoxybenzyl)-1H-Pyrazole 1-(Benzyloxy)-2-Bromobenzene 1-(Benzyloxy)-2-Chlorobenzene 1-(Benzyloxy)-2-Fluorobenzene 1-(Benzyloxy)-2-Methoxybenzene 1-(Benzyloxy)-2-Methylbenzene 1-(Benzyloxy)-2-Nitrobenzene 1-(Benzyloxy)-3-Bromobenzene 1-(Benzyloxy)-3-Chlorobenzene 1-(Benzyloxy)-3-Fluorobenzene 1-(Benzyloxy)-3-Methylbenzene 1-(Benzyloxy)-3-Nitrobenzene 1-(Benzyloxy)-4-Bromobenzene 1-(Benzyloxy)-4-Iodobenzene 1-(Bromomethyl)-2-Methoxybenzene 1-(Bromomethyl)-3-Methoxybenzene 1-(Difluoromethoxy)-2-Fluorobenzene 1-Benzyl-4-Methoxybenzene 1-Bromo-2,3-Dimethoxybenzene 1-Bromo-2-Chloro-3-Methoxybenzene 1-Bromo-2-Ethoxybenzene 1-Bromo-2-Fluoro-3-Methoxybenzene 1-Bromo-2-Phenoxybenzene 1-Bromo-3-Methoxybenzene 1-Bromo-3-Phenoxybenzene 1-Bromo-4-Phenoxybenzene 1-Chloro-2,4-Dimethoxybenzene 1-Chloro-2-Ethoxybenzene 1-Chloro-2-Phenoxybenzene 1-Chloro-2-Propoxybenzene 1-Chloro-3-Fluoro-2-Methoxybenzene 1-Chloro-3-Methoxybenzene 1-Chloro-3-Phenoxybenzene 1-Chloro-4-Methoxybenzene 1-Chloro-4-Phenoxybenzene 1-Cyclopropyl-3-(4-(Quinolin-4-Yloxy)Phenyl)Urea 1-Ethoxy-2,3-Difluorobenzene 1-Ethoxy-2-Fluorobenzene 1-Ethoxy-3-Nitrobenzene 1-Fluoro-2-(Trifluoromethoxy)Benzene 1-Fluoro-2-Isopropoxybenzene 1-Fluoro-2-Phenoxybenzene 1-Fluoro-3-Methoxybenzene 1-Fluoro-3-Phenoxybenzene 1-Fluoro-4-(Trifluoromethoxy)Benzene 1-Fluoro-4-Methoxybenzene 1-Fluoro-4-Phenoxybenzene 1-Iodo-2-Methoxybenzene 1-Iodo-3-Methoxybenzene 1-Iodo-4-Methoxybenzene 1-Iodo-4-Phenoxybenzene 1-Methoxy-2-(Trifluoromethyl)Benzene 1-Methoxy-3-(Trifluoromethoxy)Benzene 1-Methoxy-3-(Trifluoromethyl)Benzene 1-Methoxy-3-Nitrobenzene 1-Methoxy-4-(Phenoxymethyl)Benzene 1-Methoxy-4-(Trifluoromethyl)Benzene 1-Methoxy-4-Nitrobenzene 1-Methoxynaphthalene 1-Methyl-3-Phenoxybenzene 1-Nitro-2-Phenoxybenzene 1-Nitro-4-Phenoxybenzene 1-Phenoxy-3-(Trifluoromethyl)Benzene 1-Phenoxy-4-(Trifluoromethyl)Benzene 1-Phenyl-3-(4-(Pyridin-4-Yloxy)Phenyl)Urea 2,3,5,6,8,9,11,12-Octahydrobenzo[B][1,4,7,10,13]Pentaoxacyclopentadecine 2,3-Dimethoxypyridine 2,4,6-Triphenoxy-1,3,5-Triazine 2,4-Dibromo-1-Methoxybenzene 2,4-Dichloro-1-Methoxybenzene 2,4-Difluoro-1-Methoxybenzene 2,4-Dimethoxy-1-Nitrobenzene 2,4-Dimethoxypyrimidine 2,6-Dimethoxypyridine 2-(2-Methoxyphenyl)Acetic Acid 2-(3-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane 2-(3-Methoxyphenyl)Acetic Acid 2-(4-(Benzyloxy)Phenyl)Acetonitrile 2-(4-Methoxyphenyl)Acetic Acid 2-(Benzyloxy)Benzaldehyde 2-(Benzyloxy)Naphthalene 2-(Benzyloxy)Phenol 2-(Methoxymethyl)Morpholine 2-(Methoxymethyl)Pyrrolidine 2-(Phenoxymethyl)Oxirane 2-(Phenoxymethyl)Pyridine 2-(Phenoxymethyl)Tetrahydro-2H-Pyran 2-Bromo-1,3-Dimethoxybenzene 2-Bromo-1,4-Dimethoxybenzene 2-Bromo-1-Fluoro-4-Methoxybenzene 2-Bromo-1-Methoxy-3-Methylbenzene 2-Bromo-1-Methoxy-4-Methylbenzene 2-Bromo-3-Methoxypyrazine 2-Bromo-4-Methoxy-1-Nitrobenzene 2-Bromo-4-Methoxyaniline 2-Bromo-4-Methoxybenzaldehyde 2-Bromo-4-Methoxybenzoic Acid 2-Bromo-5-Methoxybenzaldehyde 2-Bromo-6-Methoxyaniline 2-Bromo-6-Methoxyphenol 2-Chloro-1,3-Dimethoxybenzene 2-Chloro-1,4-Dimethoxybenzene 2-Chloro-3-Methoxybenzaldehyde 2-Chloro-3-Methoxybenzoic Acid 2-Chloro-4-Fluoro-1-Methoxybenzene 2-Chloro-4-Methoxypyrimidine 2-Chloro-5-Methoxyaniline 2-Chloro-6-Methoxyaniline 2-Chloro-6-Methoxyphenol 2-Ethoxynaphthalene 2-Ethoxypyridine 2-Ethoxypyrimidine 2-Fluoro-1,3-Dimethoxybenzene 2-Fluoro-1-Methoxy-4-Nitrobenzene 2-Fluoro-4-Methoxyaniline 2-Fluoro-5-Methoxybenzoic Acid 2-Fluoro-5-Methoxypyridine 2-Fluoro-6-Methoxypyridine 2-Isopropoxypyridine 2-Methoxy-1,1'-Biphenyl 2-Methoxy-1,3,5-Triazine 2-Methoxy-4-Methylpyridine 2-Methoxy-5-Methylpyridine 2-Methoxy-6-Methylpyridine 2-Methoxy-6-Nitrophenol 2-Methoxybenzamide 2-Methoxybenzenesulfonyl Chloride 2-Methoxynaphthalene 2-Methoxyphenol 2-Methoxypyrazine 2-Methoxypyridine 2-Methoxypyrimidin-4-Amine 2-Methoxypyrimidine 2-Methoxythiophene 2-Methyl-N-Phenylaniline 2-Phenoxyacetonitrile 2-Phenoxyaniline 2-Phenoxybenzonitrile 2-Phenoxyethan-1-Ol 2-Phenoxypropanoic Acid 2-Phenoxypyrimidine 2-Phenoxytetrahydro-2H-Pyran 2-Phenoxythiazole 2-Propoxypyridine 3,5-Dimethoxypyridine 3-(3-Methoxyphenyl)Propanoic Acid 3-(Benzyloxy)Aniline 3-(Benzyloxy)Benzaldehyde 3-(Benzyloxy)Benzoic Acid 3-(Benzyloxy)Phenol 3-(Methoxymethyl)Morpholine 3-Chloro-2-Methoxybenzoic Acid 3-Chloro-4-Methoxyaniline 3-Chloro-4-Methoxybenzaldehyde 3-Chloro-4-Methoxybenzoic Acid 3-Ethoxypyridine 3-Fluoro-2-Methoxypyridine 3-Fluoro-4-Methoxybenzoic Acid 3-Methoxypiperidine 3-Methoxypyridazine 3-Methoxypyridine 3-Methoxythiophene 3-Phenoxyaniline 3-Phenoxybenzaldehyde 3-Phenoxybenzoic Acid 3-Phenoxybenzonitrile 3-Phenoxypropanoic Acid 3-Phenoxypyrrolidine 4-(3-Phenoxypropyl)Morpholine 4-(Benzyloxy)Aniline 4-(Benzyloxy)Benzaldehyde 4-(Benzyloxy)Benzoic Acid 4-(Benzyloxy)Phenol 4-(Difluoromethoxy)Aniline 4-(Dimethoxymethyl)Pyrimidine 4-(Phenylethynyl)Phenol 4-Chloro-2-Methoxypyrimidine 4-Chloro-5-Methoxypyrimidine 4-Chloro-6-Methoxypyrimidine 4-Ethoxypyridine 4-Ethoxypyrimidine 4-Methoxy-1,1'-Biphenyl 4-Methoxy-1H-Indazole 4-Methoxy-1H-Indole 4-Methoxy-2-Methylpyrimidine 4-Methoxy-N-Phenylaniline 4-Methoxy-N-Phenylbenzenesulfonamide 4-Methoxybenzenesulfonamide 4-Methoxypyridazine 4-Methoxypyridine 4-Methoxypyrimidin-2-Amine 4-Methoxypyrimidine 4-Phenoxyaniline 4-Phenoxybenzaldehyde 4-Phenoxybenzoic Acid 4-Phenoxypyridine 4-Phenoxypyrimidine 4-Phenoxyquinoline 4-Phenoxytetrahydro-2H-Pyran 5-(Benzyloxy)Pyrimidine 5-Fluoro-2-Methoxypyridine 5-Methoxy-1H-Benzo[D]Imidazole 5-Methoxy-1H-Indazole 5-Methoxy-1H-Indole 5-Methoxy-2-Methyl-1H-Indole 5-Methoxy-2-Nitroaniline 5-Methoxyindoline 5-Methoxyisobenzofuran-1(3H)-One 5-Methoxyisoquinoline 6-Methoxy-1,2,3,4-Tetrahydroisoquinoline 6-Methoxy-1H-Indazole 6-Methoxy-1H-Indole 6-Methoxy-1H-Pyrrolo[2,3-B]Pyridine 6-Methoxy-3,4-Dihydroisoquinolin-1(2H)-One 6-Methoxybenzo[D]Thiazole 6-Methoxybenzofuran 6-Methoxychromane 6-Methoxyisoindolin-1-One 6-Methoxyquinoxaline 7-(Benzyloxy)Quinoline 7-Methoxy-1,2,3,4-Tetrahydroisoquinoline 7-Methoxy-1H-Indazole 7-Methoxy-1H-Indole 7-Methoxy-3,4-Dihydroquinolin-2(1H)-One 7-Methoxyisoquinoline 8-Methoxyisoquinoline 8-Methoxyquinazoline Butoxybenzene Ethoxybenzene Ethyl 2-Phenoxyacetate Isobutoxybenzene Isopropoxybenzene Methoxycyclohexane Methyl 2-Methoxybenzoate Methyl 2-Phenoxyacetate Methyl 2-Phenoxybenzoate Methyl 3-(Benzyloxy)Benzoate Methyl 3-Methoxybenzoate Methyl 4-Phenoxybenzoate N,N-Dimethyl-2-Phenoxyethan-1-Amine N-(2-Phenoxyphenyl)Methanesulfonamide N-(4-Phenoxyphenyl)Acetamide N-Phenyl-N-(4-(Quinolin-4-Yloxy)Phenyl)Cyclopropane-1,1-Dicarboxamide Phenethoxybenzene Propoxybenzene Tert-Butoxybenzene Tert-Butyl 3-Methoxypyrrolidine-1-Carboxylate Tert-Butyl 4-Phenoxypiperidine-1-Carboxylate Tert-Butyl 5-Methoxy-1H-Indole-1-Carboxylate

By Key Group+−

(2-Ethylhexyl)Oxy (S)-2-Methoxyethanamine (Trimethylsilyl)Ethoxy 2,2,2-Trifluoroethoxy 2,2-Difluoroethoxy 2,2-Dimethoxyethyl 2-Bromo-1,1,2,2-Tetrafluoroethoxy 2-Bromoethoxy 2-Methoxyethoxy 2-Methoxyethoxymethyl 2-Methoxyethyl 2-Methyl-2-Oxypropanoic Acid 2-Oxoacetic Acid 2-Oxy-Propanoic Acid 3-(Oxy)Propanoic Acid 3-Methoxypropoxy 4-Bromobutoxy Allyloxy Benzo-Crown-Ether Butoxy Butoxy-Phenyl-Boronic Acid Butoxy-Phenyl-Boronic Acid/Ester Butoxy-Phenyl-Boronic-Acid Chloroanisole Cyanomethoxy Decyloxy Diethoxy Diethoxy Diethoxyethyl Diethoxyethyl Diethoxymethyl Diethoxymethyl Diethylaminoethoxy Dimethoxyethyl Dimethoxymethyl Dimethoxypropane Dimethoxypropane Dimethylamino Ethoxy Dimethylaminopropoxy Dioxane Dioxepine Dioxepine Dioxopropan Dioxopropan Disulfide Dodecyloxy Ethoxyethanol Ethyl 2-Oxyacetate Fluoromethoxy-Nitro-Benzene Heptyloxy Hexyloxy Isobutoxy Isopentyloxy Isopropoxy Isopropoxyphenylboronic Methoxy-Acetic Acid Methoxy-Benzoimidazole Methoxy-Carbazole Methoxy-Chromen-One Methoxy-Indanone Methoxy-Indazole-Carboxylate Methoxy-Inden-Amine Methoxy-Indole-Carboxylate Methoxy-Methyl-Indole Methoxy-Methylbenzene Methoxy-Naphthyridine Methoxy-Pyran Methoxy-Pyrazolo-Pyridine Methoxy-Trifluoromethyl-Benzene Methoxyacetate Methoxychroman Methoxyethoxyethoxyethoxy Methoxyphenylboronic-Acid Methyl 2-Oxy-Acetate Nitroanisole Octyloxy Oxy Ethanamine Oxy-Acetohydrazide Oxyacetic Acid Oxypropane-1,2-Dio Prop-2-Yn-1-Oxy Propoxy Tert-Butoxy Tert-Butoxybromobenzene Tert-Butoxymethyl Tetrahydroquinoline-Methoxy

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzimidazoles Benzofurans Benzothiazoles Benzothiophenes Benzoxazoles Carbazoles Dioxolanes Epoxides Furans Guanidines Imidazoles Imidazolines Indazoles Indoles Indolines Isoquinolines Isoxazoles Morpholines Naphthyridines Non-Halogenated Heterocycles Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxadiazoles Oxazoles Oxazolidines Oxetanes Piperazines Piperidines Purines Pyrans Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Pyrrolines Quinazolines Quinolines Quinoxalines Quinuclidines Spiroes Tetrahydrofurans Tetrahydroisoquinolines Tetrahydropyrans Tetrahydroquinolines Thiadiazoles Thiazoles Thiazolidines Thiophenols Triazines Triazoles

By Functional Group+−

Acyl Chlorides Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amidines Amines Anhydrides Aryls Benzyl Bromides Benzyl Chlorides Bromides Carboxylic Acid Salts Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Fluorinated Building Blocks Hydrazides Hydrazines Hydrazones Hydroxylamines Iodides Isocyanates and Isothiocyanates Ketones Nitrates and Nitrites Nitriles Nitroes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Sulfoxides Thioesters Thiols Thiophenes Thioureas Trifluoromethyls Ureas

Nitrogen related+−

R–O–R′

By Chemical Elements+−

    Bx
    Cx
    Nx
    Ox
    Fx
    Six
    Px
    Sx
    Clx
    Brx
    Ix

    Formula Weight+−

    cLogP+−

    H-Acceptors+−

    H-Donors+−

    Polar Surface Area+−

    Druglikeness+−

    NNCH/NNH+−

    sp3-Atoms+−

    Non-Aromatic Rings+−

    Aromatic Rings+−

    Rotatable Bonds+−

    By Configuration+−

    Typically In Stock
    Purity
    • Please Select
    • 99+%
    • 99%
    • 98+%
    • 98%
    • 97+%
    • 97%
    • 96+%
    • 96%
    • 95+%
    • 95%
    • 93%
    • 90+%
    • 90%
    Size
    • Please Select
    • 1mg
    • 2mg
    • 5mg
    • 10mg
    • 25mg
    • 50mg
    • 100mg
    • 250mg
    • 1g
    • 5g
    • 10g
    • 25g
    • 100g
    • 500g
    • 1000g
    • 1kg
    Clear Filters
    2-Chloro-6-fluoro-3-methoxybenzoic acid

    click to sign in and save

    A727841886499-40-798%

    2-Chloro-6-fluoro-3-methoxybenzoic acid

    $37.00/250mg

    Detail
    2-Chloro-6-fluoro-3-methoxyaniline

    click to sign in and save

    A1491561017777-58-095%

    2-Chloro-6-fluoro-3-methoxyaniline

    $70.00/250mg

    Detail
    2-Chloro-6-fluoro-3-methoxyphenylboronic acid

    click to sign in and save

    A2052521072945-77-797%

    2-Chloro-6-fluoro-3-methoxyphenylboronic acid

    $12.00/250mg

    Detail
    (3-Chloro-5-fluoro-2-methoxyphenyl)boronic acid

    click to sign in and save

    A6243372121513-76-497%

    (3-Chloro-5-fluoro-2-methoxyphenyl)boronic acid

    $104.00/5g

    Detail
    5-Bromo-2-chloro-4-fluoroanisole

    click to sign in and save

    A466471146447-18-998%

    5-Bromo-2-chloro-4-fluoroanisole

    $10.00/100mg

    Detail
    2-Chloro-4-fluoroanisole

    click to sign in and save

    A5355282267-25-698%

    2-Chloro-4-fluoroanisole

    $10.00/1g

    Detail
    1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene

    click to sign in and save

    A11353684478-76-297%

    1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene

    $10.00/100mg

    Detail
    4-Chloro-2-fluoro-5-methoxybenzaldehyde

    click to sign in and save

    A329280177034-24-195%

    4-Chloro-2-fluoro-5-methoxybenzaldehyde

    $195.00/1g

    Detail
    6-Chloro-2-(2-chloro-6-fluoro-3-methoxyphenyl)pyridazin-3(2H)-one

    click to sign in and save

    A5761782095780-75-797%

    6-Chloro-2-(2-chloro-6-fluoro-3-methoxyphenyl)pyridazin-3(2H)-one

    $140.00/50mg

    Detail
    (4-Chloro-2-fluoro-5-methoxyphenyl)boronic acid

    click to sign in and save

    A191580153122-60-298%

    (4-Chloro-2-fluoro-5-methoxyphenyl)boronic acid

    $23.00/250mg

    Detail
    1    page 1 of 1 Pages

    Inquiry