Home Chemistry Organic Building Blocks Nitriles 2-Chloro-4-Fluorobenzonitrile
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—C≡N,—F).
Electrophilic Substitution Reactions: Chlorobenzene's electron-rich aromatic ring can undergo substitution reactions where a hydrogen atom is replaced by a chlorine atom. For instance, it can undergo nitration, sulfonation, and Friedel-Crafts alkylation/acylation reactions.
Amination: Benzonitrile can be aminated using various reagents to introduce 【amine|https://www.ambeed.com/amines.html】 functional groups.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
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