Home Chemistry Organic Building Blocks Amides 2-Chloro-N-Phenylacetamide
These compounds have the same murcko framework: benzene,and at least 1 kind of functional groups( —NHC(O)CH2Cl).
Nucleophilic Substitution: The chlorine atom (Cl) in 2-chloro-N-phenylacetamide is a good leaving group, making it susceptible to nucleophilic substitution reactions. Various nucleophiles can displace the chlorine atom to form a new compound. The choice of nucleophile and reaction conditions will determine the product. Common nucleophiles include hydroxide ions (OH-) for hydrolysis to form an amide, 【amines|https://www.ambeed.com/amines.html】 for conversion to secondary or tertiary 【amines|https://www.ambeed.com/amines.html】, or Grignard reagents for further functionalization.
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2-Chloro-N-(2-methyl-4-bromophenyl)acetamide
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2-Chloro-N-(4-(trifluoromethyl)phenyl)acetamide
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2-Chloro-N-(2-ethyl-6-methylphenyl)acetamide
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2-Chloro-N-(4-(methylsulfonyl)phenyl)acetamide
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