Chemistry Organic Building Blocks Ethers 2-Fluoro-1-Methoxy-4-Nitrobenzene

2-Fluoro-1-Methoxy-4-Nitrobenzene

These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —F,—OCH3,—NO2).

Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Aluminum Chloride Demethylation: Methoxybenzene can be demethylated using aluminum chloride (AlCl3) as a catalyst, leading to the formation of 【phenol|https://www.ambeed.com/phenols.html】 and methanol.
Sulfonation: Nitrobenzene can be sulfonated to introduce a sulfonic acid group (-SO3H) onto the benzene ring. Sulfonation is carried out using concentrated sulfuric acid, which leads to the substitution of one of the hydrogen atoms on the ring.

Further Reading:

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(1S,4Ar,7Ar)-1-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-1,4A,5,7A-Tetrahydrocyclopenta[C]Pyran (2,2,2-Trifluoroethoxy)Benzene (2-(Benzyloxy)Phenyl)Boronic Acid (2-(Phenoxymethyl)Phenyl)Boronic Acid (2-Chloro-3-Methoxyphenyl)Boronic Acid (2-Chloroethoxy)Benzene (2-Methoxyethoxy)Benzene (3-(Benzyloxy)Phenyl)Boronic Acid (3-(Phenoxymethyl)Phenyl)Boronic Acid (3-Chloro-2-Methoxyphenyl)Boronic Acid (3-Phenoxyphenyl)Methanol (4-(Benzyloxy)Phenyl)Boronic Acid (4-(Phenoxymethyl)Phenyl)Boronic Acid (4-Methoxyphenyl)(Phenyl)Methanone (9H-Fluoren-9-Yl)Methyl (2-(Benzyloxy)Ethyl)Carbamate (9H-Fluoren-9-Yl)Methyl (4-Methoxybenzyl)Carbamate (Allyloxy)Benzene (Ethoxymethyl)Benzene (Hexyloxy)Benzene (Methoxymethyl)Benzene (Prop-2-Yn-1-Yloxy)Benzene (R)-2-Phenoxytetrahydro-2H-Pyran (S)-7-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-7,8,9,10-Tetrahydrotetracene-5,12-Dione 1,2-Bis(Benzyloxy)Benzene 1,2-Dichloro-3-Methoxybenzene 1,2-Dichloro-4-Methoxybenzene 1,2-Difluoro-3-Methoxybenzene 1,2-Difluoro-4-Methoxybenzene 1,2-Dimethoxybenzene 1,2-Diphenoxyethane 1,3-Bis(Benzyloxy)Benzene 1,3-Dibromo-2-Methoxybenzene 1,3-Dichloro-2-Methoxybenzene 1,3-Diiodo-2-Phenoxybenzene 1,3-Dimethoxybenzene 1,3-Diphenoxybenzene 1,4-Dichloro-2-Methoxybenzene 1,4-Dimethoxybenzene 1-(2-Methoxyphenyl)Ethan-1-One 1-(3-(Benzyloxy)Phenyl)Ethan-1-One 1-(3-Methoxyphenyl)Ethan-1-One 1-(3-Methoxyphenyl)Piperazine 1-(4-(Benzyloxy)Phenyl)Ethan-1-One 1-(4-Methoxybenzyl)-1H-Pyrazole 1-(Benzyloxy)-2-Bromobenzene 1-(Benzyloxy)-2-Chlorobenzene 1-(Benzyloxy)-2-Fluorobenzene 1-(Benzyloxy)-2-Methoxybenzene 1-(Benzyloxy)-2-Methylbenzene 1-(Benzyloxy)-2-Nitrobenzene 1-(Benzyloxy)-3-Bromobenzene 1-(Benzyloxy)-3-Chlorobenzene 1-(Benzyloxy)-3-Fluorobenzene 1-(Benzyloxy)-3-Methylbenzene 1-(Benzyloxy)-3-Nitrobenzene 1-(Benzyloxy)-4-Bromobenzene 1-(Benzyloxy)-4-Iodobenzene 1-(Bromomethyl)-2-Methoxybenzene 1-(Bromomethyl)-3-Methoxybenzene 1-(Difluoromethoxy)-2-Fluorobenzene 1-Benzyl-4-Methoxybenzene 1-Bromo-2,3-Dimethoxybenzene 1-Bromo-2-Chloro-3-Methoxybenzene 1-Bromo-2-Ethoxybenzene 1-Bromo-2-Fluoro-3-Methoxybenzene 1-Bromo-2-Phenoxybenzene 1-Bromo-3-Methoxybenzene 1-Bromo-3-Phenoxybenzene 1-Bromo-4-Phenoxybenzene 1-Chloro-2,4-Dimethoxybenzene 1-Chloro-2-Ethoxybenzene 1-Chloro-2-Phenoxybenzene 1-Chloro-2-Propoxybenzene 1-Chloro-3-Fluoro-2-Methoxybenzene 1-Chloro-3-Methoxybenzene 1-Chloro-3-Phenoxybenzene 1-Chloro-4-Methoxybenzene 1-Chloro-4-Phenoxybenzene 1-Cyclopropyl-3-(4-(Quinolin-4-Yloxy)Phenyl)Urea 1-Ethoxy-2,3-Difluorobenzene 1-Ethoxy-2-Fluorobenzene 1-Ethoxy-3-Nitrobenzene 1-Fluoro-2-(Trifluoromethoxy)Benzene 1-Fluoro-2-Isopropoxybenzene 1-Fluoro-2-Phenoxybenzene 1-Fluoro-3-Methoxybenzene 1-Fluoro-3-Phenoxybenzene 1-Fluoro-4-(Trifluoromethoxy)Benzene 1-Fluoro-4-Methoxybenzene 1-Fluoro-4-Phenoxybenzene 1-Iodo-2-Methoxybenzene 1-Iodo-3-Methoxybenzene 1-Iodo-4-Methoxybenzene 1-Iodo-4-Phenoxybenzene 1-Methoxy-2-(Trifluoromethyl)Benzene 1-Methoxy-3-(Trifluoromethoxy)Benzene 1-Methoxy-3-(Trifluoromethyl)Benzene 1-Methoxy-3-Nitrobenzene 1-Methoxy-4-(Phenoxymethyl)Benzene 1-Methoxy-4-(Trifluoromethyl)Benzene 1-Methoxy-4-Nitrobenzene 1-Methoxynaphthalene 1-Methyl-3-Phenoxybenzene 1-Nitro-2-Phenoxybenzene 1-Nitro-4-Phenoxybenzene 1-Phenoxy-3-(Trifluoromethyl)Benzene 1-Phenoxy-4-(Trifluoromethyl)Benzene 1-Phenyl-3-(4-(Pyridin-4-Yloxy)Phenyl)Urea 2,3,5,6,8,9,11,12-Octahydrobenzo[B][1,4,7,10,13]Pentaoxacyclopentadecine 2,3-Dimethoxypyridine 2,4,6-Triphenoxy-1,3,5-Triazine 2,4-Dibromo-1-Methoxybenzene 2,4-Dichloro-1-Methoxybenzene 2,4-Difluoro-1-Methoxybenzene 2,4-Dimethoxy-1-Nitrobenzene 2,4-Dimethoxypyrimidine 2,6-Dimethoxypyridine 2-(2-Methoxyphenyl)Acetic Acid 2-(3-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane 2-(3-Methoxyphenyl)Acetic Acid 2-(4-(Benzyloxy)Phenyl)Acetonitrile 2-(4-Methoxyphenyl)Acetic Acid 2-(Benzyloxy)Benzaldehyde 2-(Benzyloxy)Naphthalene 2-(Benzyloxy)Phenol 2-(Methoxymethyl)Morpholine 2-(Methoxymethyl)Pyrrolidine 2-(Phenoxymethyl)Oxirane 2-(Phenoxymethyl)Pyridine 2-(Phenoxymethyl)Tetrahydro-2H-Pyran 2-Bromo-1,3-Dimethoxybenzene 2-Bromo-1,4-Dimethoxybenzene 2-Bromo-1-Fluoro-4-Methoxybenzene 2-Bromo-1-Methoxy-3-Methylbenzene 2-Bromo-1-Methoxy-4-Methylbenzene 2-Bromo-3-Methoxypyrazine 2-Bromo-4-Methoxy-1-Nitrobenzene 2-Bromo-4-Methoxyaniline 2-Bromo-4-Methoxybenzaldehyde 2-Bromo-4-Methoxybenzoic Acid 2-Bromo-5-Methoxybenzaldehyde 2-Bromo-6-Methoxyaniline 2-Bromo-6-Methoxyphenol 2-Chloro-1,3-Dimethoxybenzene 2-Chloro-1,4-Dimethoxybenzene 2-Chloro-3-Methoxybenzaldehyde 2-Chloro-3-Methoxybenzoic Acid 2-Chloro-4-Fluoro-1-Methoxybenzene 2-Chloro-4-Methoxypyrimidine 2-Chloro-5-Methoxyaniline 2-Chloro-6-Methoxyaniline 2-Chloro-6-Methoxyphenol 2-Ethoxynaphthalene 2-Ethoxypyridine 2-Ethoxypyrimidine 2-Fluoro-1,3-Dimethoxybenzene 2-Fluoro-1-Methoxy-4-Nitrobenzene 2-Fluoro-4-Methoxyaniline 2-Fluoro-5-Methoxybenzoic Acid 2-Fluoro-5-Methoxypyridine 2-Fluoro-6-Methoxypyridine 2-Isopropoxypyridine 2-Methoxy-1,1'-Biphenyl 2-Methoxy-1,3,5-Triazine 2-Methoxy-4-Methylpyridine 2-Methoxy-5-Methylpyridine 2-Methoxy-6-Methylpyridine 2-Methoxy-6-Nitrophenol 2-Methoxybenzamide 2-Methoxybenzenesulfonyl Chloride 2-Methoxynaphthalene 2-Methoxyphenol 2-Methoxypyrazine 2-Methoxypyridine 2-Methoxypyrimidin-4-Amine 2-Methoxypyrimidine 2-Methoxythiophene 2-Methyl-N-Phenylaniline 2-Phenoxyacetonitrile 2-Phenoxyaniline 2-Phenoxybenzonitrile 2-Phenoxyethan-1-Ol 2-Phenoxypropanoic Acid 2-Phenoxypyrimidine 2-Phenoxytetrahydro-2H-Pyran 2-Phenoxythiazole 2-Propoxypyridine 3,5-Dimethoxypyridine 3-(3-Methoxyphenyl)Propanoic Acid 3-(Benzyloxy)Aniline 3-(Benzyloxy)Benzaldehyde 3-(Benzyloxy)Benzoic Acid 3-(Benzyloxy)Phenol 3-(Methoxymethyl)Morpholine 3-Chloro-2-Methoxybenzoic Acid 3-Chloro-4-Methoxyaniline 3-Chloro-4-Methoxybenzaldehyde 3-Chloro-4-Methoxybenzoic Acid 3-Ethoxypyridine 3-Fluoro-2-Methoxypyridine 3-Fluoro-4-Methoxybenzoic Acid 3-Methoxypiperidine 3-Methoxypyridazine 3-Methoxypyridine 3-Methoxythiophene 3-Phenoxyaniline 3-Phenoxybenzaldehyde 3-Phenoxybenzoic Acid 3-Phenoxybenzonitrile 3-Phenoxypropanoic Acid 3-Phenoxypyrrolidine 4-(3-Phenoxypropyl)Morpholine 4-(Benzyloxy)Aniline 4-(Benzyloxy)Benzaldehyde 4-(Benzyloxy)Benzoic Acid 4-(Benzyloxy)Phenol 4-(Difluoromethoxy)Aniline 4-(Dimethoxymethyl)Pyrimidine 4-(Phenylethynyl)Phenol 4-Chloro-2-Methoxypyrimidine 4-Chloro-5-Methoxypyrimidine 4-Chloro-6-Methoxypyrimidine 4-Ethoxypyridine 4-Ethoxypyrimidine 4-Methoxy-1,1'-Biphenyl 4-Methoxy-1H-Indazole 4-Methoxy-1H-Indole 4-Methoxy-2-Methylpyrimidine 4-Methoxy-N-Phenylaniline 4-Methoxy-N-Phenylbenzenesulfonamide 4-Methoxybenzenesulfonamide 4-Methoxypyridazine 4-Methoxypyridine 4-Methoxypyrimidin-2-Amine 4-Methoxypyrimidine 4-Phenoxyaniline 4-Phenoxybenzaldehyde 4-Phenoxybenzoic Acid 4-Phenoxypyridine 4-Phenoxypyrimidine 4-Phenoxyquinoline 4-Phenoxytetrahydro-2H-Pyran 5-(Benzyloxy)Pyrimidine 5-Fluoro-2-Methoxypyridine 5-Methoxy-1H-Benzo[D]Imidazole 5-Methoxy-1H-Indazole 5-Methoxy-1H-Indole 5-Methoxy-2-Methyl-1H-Indole 5-Methoxy-2-Nitroaniline 5-Methoxyindoline 5-Methoxyisobenzofuran-1(3H)-One 5-Methoxyisoquinoline 6-Methoxy-1,2,3,4-Tetrahydroisoquinoline 6-Methoxy-1H-Indazole 6-Methoxy-1H-Indole 6-Methoxy-1H-Pyrrolo[2,3-B]Pyridine 6-Methoxy-3,4-Dihydroisoquinolin-1(2H)-One 6-Methoxybenzo[D]Thiazole 6-Methoxybenzofuran 6-Methoxychromane 6-Methoxyisoindolin-1-One 6-Methoxyquinoxaline 7-(Benzyloxy)Quinoline 7-Methoxy-1,2,3,4-Tetrahydroisoquinoline 7-Methoxy-1H-Indazole 7-Methoxy-1H-Indole 7-Methoxy-3,4-Dihydroquinolin-2(1H)-One 7-Methoxyisoquinoline 8-Methoxyisoquinoline 8-Methoxyquinazoline Butoxybenzene Ethoxybenzene Ethyl 2-Phenoxyacetate Isobutoxybenzene Isopropoxybenzene Methoxycyclohexane Methyl 2-Methoxybenzoate Methyl 2-Phenoxyacetate Methyl 2-Phenoxybenzoate Methyl 3-(Benzyloxy)Benzoate Methyl 3-Methoxybenzoate Methyl 4-Phenoxybenzoate N,N-Dimethyl-2-Phenoxyethan-1-Amine N-(2-Phenoxyphenyl)Methanesulfonamide N-(4-Phenoxyphenyl)Acetamide N-Phenyl-N-(4-(Quinolin-4-Yloxy)Phenyl)Cyclopropane-1,1-Dicarboxamide Phenethoxybenzene Propoxybenzene Tert-Butoxybenzene Tert-Butyl 3-Methoxypyrrolidine-1-Carboxylate Tert-Butyl 4-Phenoxypiperidine-1-Carboxylate Tert-Butyl 5-Methoxy-1H-Indole-1-Carboxylate

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(2-Ethylhexyl)Oxy (S)-2-Methoxyethanamine (Trimethylsilyl)Ethoxy 2,2,2-Trifluoroethoxy 2,2-Difluoroethoxy 2,2-Dimethoxyethyl 2-Bromo-1,1,2,2-Tetrafluoroethoxy 2-Bromoethoxy 2-Methoxyethoxy 2-Methoxyethoxymethyl 2-Methoxyethyl 2-Methyl-2-Oxypropanoic Acid 2-Oxoacetic Acid 2-Oxy-Propanoic Acid 3-(Oxy)Propanoic Acid 3-Methoxypropoxy 4-Bromobutoxy Allyloxy Benzo-Crown-Ether Butoxy Butoxy-Phenyl-Boronic Acid Butoxy-Phenyl-Boronic Acid/Ester Butoxy-Phenyl-Boronic-Acid Chloroanisole Cyanomethoxy Decyloxy Diethoxy Diethoxy Diethoxyethyl Diethoxyethyl Diethoxymethyl Diethoxymethyl Diethylaminoethoxy Dimethoxyethyl Dimethoxymethyl Dimethoxypropane Dimethoxypropane Dimethylamino Ethoxy Dimethylaminopropoxy Dioxane Dioxepine Dioxepine Dioxopropan Dioxopropan Disulfide Dodecyloxy Ethoxyethanol Ethyl 2-Oxyacetate Fluoromethoxy-Nitro-Benzene Heptyloxy Hexyloxy Isobutoxy Isopentyloxy Isopropoxy Isopropoxyphenylboronic Methoxy-Acetic Acid Methoxy-Benzoimidazole Methoxy-Carbazole Methoxy-Chromen-One Methoxy-Indanone Methoxy-Indazole-Carboxylate Methoxy-Inden-Amine Methoxy-Indole-Carboxylate Methoxy-Methyl-Indole Methoxy-Methylbenzene Methoxy-Naphthyridine Methoxy-Pyran Methoxy-Pyrazolo-Pyridine Methoxy-Trifluoromethyl-Benzene Methoxyacetate Methoxychroman Methoxyethoxyethoxyethoxy Methoxyphenylboronic-Acid Methyl 2-Oxy-Acetate Nitroanisole Octyloxy Oxy Ethanamine Oxy-Acetohydrazide Oxyacetic Acid Oxypropane-1,2-Dio Prop-2-Yn-1-Oxy Propoxy Tert-Butoxy Tert-Butoxybromobenzene Tert-Butoxymethyl Tetrahydroquinoline-Methoxy

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