The 2OG (2-oxoglutarate) Oxygenase family is a group of enzymes that depend on 2-oxoglutarate and oxygen molecules, including several members such as prolyl hydroxylases, histone demethylases, and DNA demethylases. These enzymes typically contain a non-heme iron binding site and are mainly located in the cell nucleus and cytoplasm. The 2OG oxygenase family is involved in regulating various biological processes, including post-translational modifications of proteins, epigenetic modifications, and cellular metabolism, by catalyzing hydroxylation, demethylation, or cleavage of substrates, affecting cell growth, differentiation, and stress responses. The expression of 2OG oxygenase family members varies in different tissues and cells, and their gene mutations or expression abnormalities are associated with various diseases, including tumors, cardiovascular diseases, and neurodegenerative diseases.