Home Chemistry Heterocyclic Building Blocks Piperidines 3,3-Difluoropiperidine
Nucleophilic Substitution: The fluorine atoms on the piperidine ring can undergo nucleophilic substitution reactions, particularly with strong nucleophiles, leading to the formation of substituted piperidine derivatives.
Alkylation: The nitrogen atom in the piperidine ring can be alkylated by reaction with alkyl halides or sulfonates.
Acylation: The nitrogen atom in the piperidine ring can undergo acylation reactions to form N-acyl derivatives.
Reduction: The piperidine ring can be reduced using various reducing agents to form the corresponding saturated piperidine derivatives.
Nucleophilic Fluorination: The piperidine ring can undergo nucleophilic fluorination reactions, particularly at the 3-position, to introduce fluorine atoms.
Ring-opening Reactions: The piperidine ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Cyclization Reactions: 3,3-difluoropiperidine can undergo cyclization reactions with suitable reagents to form heterocyclic compounds.
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3,3-Difluoropiperidine-4,4-diol hydrochloride
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1-tert-Butyl 3-ethyl 5,5-difluoropiperidine-1,3-dicarboxylate
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(5,5-Difluoropiperidin-3-yl)methanol hydrochloride
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tert-Butyl 5-amino-3,3-difluoropiperidine-1-carboxylate
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(R)-tert-Butyl 5-amino-3,3-difluoropiperidine-1-carboxylate
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(S)-tert-Butyl 5-amino-3,3-difluoropiperidine-1-carboxylate
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tert-Butyl (S)-(5,5-difluoropiperidin-3-yl)carbamate
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tert-Butyl 3,3-difluoropiperidine-1-carboxylate
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1-tert-Butyl 2-methyl 5,5-difluoropiperidine-1,2-dicarboxylate
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1-tert-Butyl 3-methyl 5,5-difluoropiperidine-1,3-dicarboxylate
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1-(tert-Butoxycarbonyl)-5,5-difluoropiperidine-3-carboxylic acid
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tert-Butyl (3,3-difluoropiperidin-4-yl)carbamate
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(3,3-Difluoropiperidin-4-yl)methanol hydrochloride
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tert-Butyl 4-(aminomethyl)-3,3-difluoropiperidine-1-carboxylate
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1-[(tert-butoxy)carbonyl]-3,3-difluoropiperidine-4-carboxylic acid
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tert-Butyl 4-(ethylamino)-3,3-difluoropiperidine-1-carboxylate
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tert-Butyl 4-(2-aminoethyl)-3,3-difluoropiperidine-1-carboxylate
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1-tert-Butyl 4-methyl 3,3-difluoropiperidine-1,4-dicarboxylate
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1-tert-Butyl 4-ethyl 3,3-difluoropiperidine-1,4-dicarboxylate
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