Home Chemistry Heterocyclic Building Blocks Oxazolidines 3-(4-Morpholinophenyl)Oxazolidin-2-One
Acylation: The oxazolidin-2-one ring can undergo acylation with acyl chlorides or anhydrides to form amides.
Reduction: The carbonyl group can be reduced to the corresponding alcohol using reducing agents such as lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Ring Opening: The oxazolidin-2-one ring can be opened under acidic or basic conditions, yielding a primary amine and a carboxylic acid.
Nucleophilic Substitution: The compound can undergo nucleophilic substitution reactions at the oxazolidinone carbonyl group with nucleophiles such as amines or hydrazines to form substituted derivatives.
Alkylation: The phenyl ring with a morpholine substituent can be alkylated using alkyl halides or alkylating agents in the presence of a base.
Heterocyclization: Depending on the reaction conditions, it may participate in various heterocyclization reactions to form different heterocyclic compounds.
Hydrolysis: The compound can undergo hydrolysis under acidic or basic conditions to break the oxazolidin-2-one ring, yielding a carboxylic acid and aminomorpholine derivative.
Amide Formation: The amine group can react with acid chlorides or anhydrides to form amide derivatives.
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(R)-5-(Chloromethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one
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(R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate
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