Home Chemistry Heterocyclic Building Blocks Piperidines 3-Fluoropiperidine
Substitution Reactions: The fluorine atom can undergo substitution reactions, such as nucleophilic substitution, electrophilic substitution, or metal-catalyzed substitution, leading to the formation of substituted piperidines.
Reduction: The fluorine atom can be reduced to a hydrogen atom under appropriate conditions, such as using reducing agents like lithium aluminum hydride or hydrogen gas over a metal catalyst.
Nucleophilic Fluorination: The piperidine ring can undergo nucleophilic fluorination reactions, where a nucleophilic fluorine source replaces another atom or functional group, leading to the formation of 3-fluoropiperidine.
Acylation: The nitrogen atom in the piperidine ring can undergo acylation reactions to form N-acyl derivatives.
Ring-opening Reactions: The piperidine ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Halogenation: The piperidine ring can undergo halogenation reactions, where other halogen atoms can replace the fluorine atom under appropriate conditions.
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(3R,4R)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate
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tert-Butyl 3-fluoro-4-hydroxy-4-(trifluoromethyl)piperidine-1-carboxylate
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1-tert-Butyl 4-ethyl 3-fluoro-4-methylpiperidine-1,4-dicarboxylate
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tert-Butyl (trans-3-fluoropiperidin-4-yl)carbamate
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1-(tert-Butoxycarbonyl)-5-fluoropiperidine-3-carboxylic acid
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1-tert-Butyl 3-ethyl 5-fluoropiperidine-1,3-dicarboxylate
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(3S,5S)-tert-Butyl 3-amino-5-fluoropiperidine-1-carboxylate
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tert-Butyl ((3S,5S)-5-fluoropiperidin-3-yl)carbamate
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tert-Butyl ((3R,5R)-5-fluoropiperidin-3-yl)carbamate
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tert-Butyl 3-fluoro-4-(hydroxymethyl)-4-methylpiperidine-1-carboxylate
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(3S,4R)-1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
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(3R,4S)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate
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tert-Butyl (R)-3-fluoro-4,4-dihydroxypiperidine-1-carboxylate
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tert-Butyl 3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
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(3R,4R)-rel-tert-Butyl 3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
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(3S,4R)-rel-tert-Butyl 3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
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tert-Butyl 4-(Aminomethyl)-3-fluoropiperidine-1-carboxylate
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1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
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trans-1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
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