Home Chemistry Heterocyclic Building Blocks Piperidines 3-Methylpiperidine
Substitution Reactions: The nitrogen atom can undergo substitution reactions with various electrophiles, such as alkyl halides or acyl chlorides, leading to the formation of N-substituted piperidines.
N-Alkylation: The nitrogen atom can be alkylated by reaction with alkyl halides or sulfonates, leading to the formation of N-alkylated piperidines.
N-Acylation: The nitrogen atom can undergo acylation reactions to form N-acyl derivatives of piperidine.
Ring-opening Reactions: The piperidine ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Reduction: The nitrogen-carbon double bond can be reduced to form the corresponding secondary amine using reducing agents such as hydrogen gas over a metal catalyst or hydride reagents.
Oxidation: The nitrogen atom can be oxidized to form the corresponding imine or iminium ion under suitable conditions.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Protonation: The nitrogen atom can be protonated under acidic conditions to form the corresponding ammonium salt.
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cis-1-(tert-Butoxycarbonyl)-3-methylpiperidine-2-carboxylic acid
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tert-Butyl 4-hydroxy-3-methylpiperidine-1-carboxylate
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rel-(3R,4S)-tert-Butyl 4-hydroxy-3-methylpiperidine-1-carboxylate
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tert-Butyl (3R,4R)-4-amino-3-methylpiperidine-1-carboxylate
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4,4-Difluoro-3-methylpiperidine hydrochloride
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