Home Chemistry Heterocyclic Building Blocks Indazoles 4-Fluoro-1H-Indazole
Substitution Reactions: The fluorine atom can undergo substitution reactions with various nucleophiles or electrophiles, leading to the formation of substituted indazoles.
Reduction: The nitro group, if present, can be reduced to the corresponding amino group using reducing agents such as iron and hydrochloric acid (Fe/HCl) or tin and hydrochloric acid (Sn/HCl).
Acylation: The nitrogen atom in the indazole ring can undergo acylation reactions to form N-acyl derivatives.
Alkylation: The nitrogen atom in the indazole ring can be alkylated by reaction with alkyl halides or sulfonates.
Oxidation: If containing reducible functional groups, oxidation reactions can occur under appropriate conditions to form oxidized derivatives.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Ring-opening Reactions: The indazole ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Halogenation: Other halogen atoms can be introduced into the molecule through halogenation reactions using appropriate halogenating agents.
Nucleophilic Aromatic Substitution (SNAr): The fluorine atom can undergo SNAr reactions with nucleophiles, leading to substitution at the 4-position of the indazole ring.
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Methyl 4-fluoro-1H-indazole-6-carboxylate
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Methyl 3-bromo-4-fluoro-1H-indazole-6-carboxylate
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4-Fluoro-1H-indazole-5-carboxylic acid
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6-Bromo-4-fluoro-3-methyl-1H-indazole
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