Home Chemistry Heterocyclic Building Blocks Piperidines 4-Methylenepiperidine
Nucleophilic Addition: The methylene group can react with nucleophiles, such as Grignard reagents, to form new carbon-carbon bonds.
Reductive Amination: 4-Methylenepiperidine can undergo reductive amination with various amines and reducing agents to form substituted piperidines.
Halogenation: It can be halogenated using halogenating reagents like bromine or chlorine.
Acylation: It can undergo acylation reactions with acyl halides or anhydrides to form amides or esters.
Oxidation: The compound can be oxidized using various oxidizing agents to form functional groups like ketones or carboxylic acids.
Reduction: The double bond in 4-methylenepiperidine can be reduced to form saturated piperidine derivatives.
Alkylation: It can be alkylated at the nitrogen atom with alkyl halides or sulfonate esters to introduce substituents at the piperidine nitrogen.
Ring-opening reactions: The piperidine ring can undergo ring-opening reactions under certain conditions.
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