Home Chemistry Heterocyclic Building Blocks Pyrazoles 4-Phenyl-1H-Pyrazole
Substitution Reactions: The phenyl group can undergo electrophilic aromatic substitution reactions, such as Friedel-Crafts acylation or alkylation.
Diazotization: You can diazotize the amino group on the pyrazole ring by treating it with sodium nitrite and acid. This reaction forms a diazonium salt, which can then be used in various coupling reactions, such as the Sandmeyer reaction.
Ring Modification: The pyrazole ring can undergo various ring-modifying reactions, such as N-alkylation or N-acylation.
Reduction: The carbonyl group in the pyrazole can be reduced to an alcohol using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Oxidation: The alcohol group, if formed, can be oxidized to a carbonyl group (aldehyde or ketone) using oxidizing agents.
Condensation Reactions: 4-Phenyl-1H-pyrazole can participate in condensation reactions with other compounds. For example, it can undergo a reaction with hydrazine to form pyrazolones.
Arylation and Alkylation: The pyrazole ring can be further functionalized through arylation and alkylation reactions at various positions.
Cyclization: Depending on the reaction conditions and reagents, further cyclization reactions may occur, leading to the formation of more complex heterocyclic compounds.
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4-(4-(tert-Butyl)phenyl)-1H-pyrazol-3-amine
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4-(4-Bromophenyl)-3-methyl-1H-pyrazol-5-amine
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