Home Chemistry Heterocyclic Building Blocks Thiophenes 4H-Thieno[3,2-B]Pyrrole
Aromatic Substitution: Like other aromatic compounds, 4H-thieno[3,2-b]pyrrole can undergo electrophilic aromatic substitution reactions. For example, it can react with strong electrophiles (e.g., nitration or sulfonation reagents) to substitute one of its hydrogen atoms with the electrophile.
Nucleophilic Substitution: If there are suitable leaving groups on the molecule, nucleophilic substitution reactions can occur. For example, if there is a halogen substituent (e.g., bromine or chlorine), it can be replaced by a nucleophile in the presence of a suitable nucleophilic reagent.
Oxidation and Reduction: 4H-thieno[3,2-b]pyrrole can undergo oxidation or reduction reactions depending on the reaction conditions. For example, it can be oxidized to form 4-thieno[3,2-b]pyrrole-5-carboxylic acid under certain conditions.
Functional Group Transformations: Like many organic compounds, it can undergo various functional group transformations. For instance, it can be converted to its corresponding amine by reducing any carbonyl group present in the molecule.
Condensation Reactions: 4H-thieno[3,2-b]pyrrole can participate in condensation reactions with suitable reagents to form various products. For instance, it can undergo a Mannich reaction when treated with formaldehyde and a primary amine.
Metal-Catalyzed Reactions: Transition metal catalysts can enable various reactions with 4H-thieno[3,2-b]pyrrole, such as cross-coupling reactions or hydrogenation reactions.
Cycloaddition Reactions: Depending on the reactants and reaction conditions, it may undergo cycloaddition reactions, such as Diels-Alder reactions or 1,3-dipolar cycloadditions, to form fused or bridged ring systems.
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6-Formyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
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Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate
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2-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
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Ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate
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Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate
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