Home Chemistry Heterocyclic Building Blocks Tetrazoles 5-Phenyl-1H-Tetrazole
Substitution Reactions: The phenyl group in 5-phenyl-1H-tetrazole can undergo substitution reactions, such as electrophilic aromatic substitution or nucleophilic aromatic substitution.
Hydrolysis: 5-phenyl-1H-tetrazole can be hydrolyzed in acidic or alkaline conditions to yield different products. In acidic conditions, it can form phenylhydrazine and hydrazoic acid. In alkaline conditions, it can undergo a rearrangement to form phenylamine and ammonia.
Oxidation Reactions: 5-phenyl-1H-tetrazole can be oxidized to yield various products, depending on the oxidizing agent and reaction conditions. Oxidation may lead to the formation of diazo compounds or other derivatives.
Cycloaddition Reactions: It can participate in cycloaddition reactions, such as [3+2] cycloaddition with alkynes or other dipolarophiles to form various cyclic products.
Metal-Catalyzed Reactions: Metal-catalyzed reactions can be employed for various transformations, including C-C bond formation, C-N bond formation, and more.
Reduction Reactions: 5-phenyl-1H-tetrazole can be reduced to form various products, depending on the reducing agent and reaction conditions.
Functional Group Transformations: Various functional group transformations, including acylation, alkylation, and halogenation reactions, can be carried out on 5-phenyl-1H-tetrazole to introduce new functional groups.
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5-(4-Bromo-2-methylphenyl)-1H-tetrazole
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1,3-Benzenedicarboxylic acid, 5-(2H-tetrazol-5-yl)-
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(2-(1H-Tetrazol-5-yl)phenyl)boronic acid
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5-(2-Amino-4-chloro-5-sulfamoylphenyl)-1H-tetrazole
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