ACC (Acetyl-CoA Carboxylase) is a key enzyme involved in fatty acid synthesis, converting acetyl-CoA to malonyl-CoA. The main family members include ACC1 and ACC2, which consist of multiple functional domains and are primarily located in the cytoplasm. ACC plays a crucial role in regulating fatty acid synthesis, energy metabolism, and insulin sensitivity. The expression of ACC is tissue-specific, and mutations or dysregulation in its gene are associated with various diseases, including obesity, diabetes, and non-alcoholic fatty liver disease.