Aliphatic fluorinated building blocks are organic compounds characterized by the presence of one or more fluorine atoms attached to aliphatic (non-aromatic) carbon chains. These molecules play a critical role in modern synthetic chemistry due to the unique physicochemical properties conferred by fluorine, such as increased lipophilicity, metabolic stability, and altered electronic characteristics. Fluorine's high electronegativity and small size allow it to modulate the reactivity and biological behavior of organic molecules without significantly increasing steric bulk. Aliphatic fluorinated groups-such as trifluoromethyl (-CF₃), difluoromethylene (-CF₂-), or monofluoroalkyl chains-are commonly incorporated into pharmaceuticals, agrochemicals, and advanced materials to enhance performance. In drug discovery, these building blocks are used to improve the pharmacokinetics, bioavailability, and binding affinity of lead compounds. They are also key intermediates in the synthesis of fluorinated amino acids, fluorinated alcohols, and fluorinated surfactants. Additionally, aliphatic fluorinated compounds are widely utilized in radiochemistry, particularly for positron emission tomography (PET) imaging through isotopic fluorine-18 labeling. With the growing demand for fluorinated molecules in medicinal and materials chemistry, aliphatic fluorinated building blocks have become indispensable tools in the design and development of next-generation functional molecules.