AUTACs (Autophagy-Targeting Compounds) are a class of small-molecule compounds designed to degrade specific proteins through the autophagy pathway. They achieve selective protein degradation by binding to target proteins and promoting their association with autophagic markers such as LC3. AUTACs can be localized to various cellular compartments, including the cytoplasm and specific organelles, thereby influencing various biological responses and signaling pathways, such as cell growth, differentiation, and death. Their design can target genes with unique expression patterns or mutations, offering a potential therapeutic approach, especially for proteins that are challenging to target using traditional methods.