Catalysts Ligands Chiral Phosphine Ligands Chiral Phosphoramidite Ligands

Chiral Phosphoramidite Ligands

Chiral phosphoramidite ligands are monodentate or bidentate P(III) ligands derived from chiral diols such as BINOL, TADDOL, or other C₂-symmetric frameworks. They feature a phosphorus center bonded to an amino group and one or more oxygen atoms, typically forming a highly tunable ligand scaffold. These ligands are well known for their high enantioselectivity and have found wide application in asymmetric catalysis, particularly in Cu-, Pd-, and Ir-catalyzed transformations. One of their hallmark uses is in asymmetric allylic alkylation (AAA), where they deliver excellent regio- and enantioselectivity. They are also effective in asymmetric hydrogenation and C–H activation reactions. The modular structure of phosphoramidites allows for extensive variation of both steric and electronic properties, making them ideal for ligand optimization. Their ease of synthesis, air stability (in some cases), and ability to fine-tune both bite angles and donor characteristics have made them invaluable in both academic research and industrial catalysis.
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(11bR)-2,6-Bis(diphenylphosphino)-N,N-dimethyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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A1006200913617-04-697%

(11bR)-2,6-Bis(diphenylphosphino)-N,N-dimethyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

$52.00/50mg

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(3aS,8aS)-(2,2-Dimethyl-4,4,8,8-tetraphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl)dimethylamine

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A146234582300-09-298%

(3aS,8aS)-(2,2-Dimethyl-4,4,8,8-tetraphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl)dimethylamine

$31.00/100mg

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(11bS)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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A796324497883-22-498% 99%ee

(11bS)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

$35.00/100mg

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(S)-N,N-Diisopropyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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A415181185449-85-898% 99%ee

(S)-N,N-Diisopropyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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(R)-N,N-Dimethyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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A145360157488-65-895%

(R)-N,N-Dimethyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

$10.00/250mg

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(11bS)-N,N-Bis[(1S)-1-phenylethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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A1002597209482-27-997% 99%ee

(11bS)-N,N-Bis[(1S)-1-phenylethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

$43.00/100mg

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(11bR)-8,9,10,11,12,13,14,15-Octahydro-N,Nbis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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A1780201389329-66-198%

(11bR)-8,9,10,11,12,13,14,15-Octahydro-N,Nbis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

$52.00/100mg

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(S)-(3,5-Dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-5H-dibenz[b,f]azepine

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A857931942939-38-098% 99%ee

(S)-(3,5-Dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-5H-dibenz[b,f]azepine

$19.00/100mg

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(11aR)-10,11,12,13-Tetrahydro-N,N,3,7-tetramethyl-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-amine

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A613506930784-57-998%

(11aR)-10,11,12,13-Tetrahydro-N,N,3,7-tetramethyl-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-amine

$281.00/100mg

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(S)-2-(1-Naphthyl)-8-diphenylphosphino-1-[(R)-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl]-1,2-dihydroquinoline

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A4010631242168-77-998%

(S)-2-(1-Naphthyl)-8-diphenylphosphino-1-[(R)-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl]-1,2-dihydroquinoline

$886.00/250mg

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(2S)-(11bS)-1-(Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoline

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A10058401619901-87-995%

(2S)-(11bS)-1-(Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoline

$106.00/100mg

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N,N-Dipropyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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A287873N/A97%

N,N-Dipropyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

$266.00/1g

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(11bS)-2,6-Dimethyl-N,N-bis(1-phenylethyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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A1006119201732-49-295%

(11bS)-2,6-Dimethyl-N,N-bis(1-phenylethyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

$137.00/250mg

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N-Methyl-N-[(S)-1-phenylethyl]-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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A1189586712352-04-097%

N-Methyl-N-[(S)-1-phenylethyl]-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

$172.00/100mg

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(3aR,8aR)-2,2-Dimethyl-4,4,8,8-tetraphenyl-N,N-bis((R)-1-phenylethyl)tetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-amine

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A12200501226495-37-997%

(3aR,8aR)-2,2-Dimethyl-4,4,8,8-tetraphenyl-N,N-bis((R)-1-phenylethyl)tetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-amine

$263.00/100mg

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11bR-N,N-bis[(1R)-1-(1-naphthalenyl)ethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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A1354018676127-12-195%

11bR-N,N-bis[(1R)-1-(1-naphthalenyl)ethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

$129.00/50mg

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(11aS)-N,N-Bis((S)-1-phenylethyl)-4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine

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A1486950851890-80-798%

(11aS)-N,N-Bis((S)-1-phenylethyl)-4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine

$351.00/1g

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N,N-Bis((R)-1-phenylethyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

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A310713712352-08-498%

N,N-Bis((R)-1-phenylethyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

$222.00/250mg

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