Cholecystokinin receptors (CCKR) primarily include CCKAR (CCK1 receptor) and CCKBR (CCK2 receptor), belonging to the G protein-coupled receptor (GPCR) family. These receptors consist of seven transmembrane helical structures. CCKAR is predominantly expressed in the gastrointestinal tract and pancreas, while CCKBR is expressed in the gastrointestinal tract, brain, and pancreas. CCK receptors, upon binding to cholecystokinin (CCK), participate in regulating processes such as food intake, gastrointestinal motility, pancreatic enzyme secretion, and bile secretion. Activation of signaling pathways includes cAMP, IP3/DAG, and MAPK. Gene-specific expression and mutations are associated with various diseases such as gastrointestinal dysfunction, pancreatitis, and gastrointestinal cancer.