Choleretics are a category of drugs or substances that can increase the volume of bile secreted by the liver or improve the quality of bile. These substances include natural sources such as Scutellaria baicalensis (baikal skullcap) and burdock root, as well as synthetic medications like ursodeoxycholic acid. They primarily act on liver cells, stimulating the synthesis and secretion of bile acids, thereby facilitating fat digestion and absorption. Choleretics are involved in the liver's bile acid metabolic signaling pathways, helping to maintain digestive system health. Their effectiveness may be influenced by individual genetic differences; for example, specific gene mutations may alter the metabolic rate of the drug or the efficiency of bile acid synthesis, affecting the efficacy of choleretics.