ClpP (Caseinolytic protease P) is a serine protease that forms a large protein complex with chaperone molecules such as ClpX, mainly involved in protein degradation and quality control. ClpP is typically expressed in bacteria and mitochondria, and its structure usually comprises cylindrical complexes of 14 or 28 subunits. This enzyme plays a critical role in cellular stress response and the clearance of damaged proteins. It is expressed at higher levels in specific tissues like the heart and liver. Dysfunctional mutations in ClpP can lead to metabolic disorders and neurodegenerative diseases.