DCLK (Doublecortin-Like Kinase) refers to a class of kinases associated with cell proliferation and differentiation, primarily including family members like DCLK1 and DCLK2. These kinases contain multiple structural domains, including protein kinase domains and doublecortin protein-binding domains, mainly localized in the cytoplasm and cell membrane. DCLK plays roles in various cellular signaling pathways, particularly significant in neurodevelopment and tumor biology. The specificity of gene expression and mutations in DCLK are closely linked to neurodegenerative diseases and certain types of cancers, highlighting its importance in maintaining normal cellular functions and pathological states.