Home E3 Ligand Plus Linker (VH032)
Victoria and Chad outlined a label-free approach to evaluate the permeability of various VH032-based PROTACs and their components. This method combines a parallel artificial membrane permeability assay (PAMPA) with a lipophilic permeability efficiency (LPE) metric. Their findings indicate that the integration of these two cell-free membrane permeability assays yields novel insights into the relationships between PROTAC structure and permeability. This approach provides a conceptual framework for predicting the physicochemical properties of PROTACs, thereby enhancing the design of more permeable and effective degraders.
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