Home Functionalized E3 Ligand (Pomalidomide)
Stefanie developed and produced homobifunctional PROTACs based on pomalidomide, examining their capacity to initiate self-directed ubiquitination and degradation of CRBN. In this scenario, CRBN acts as both the E3 ubiquitin ligase and the target simultaneously. Compound 8 of the homo-PROTAC efficiently degrades CRBN with high potency, while causing only minimal residual effects on IKZF1 and IKZF3.
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