Home Functionalized E3 Ligand (VH032)
Zhang engineered a nucleic acid-conjugated PROTAC, ERE-PROTAC, through a click reaction. In this design, the ERE sequence recruits ERα, while the conventional small molecule VH032 recruits the von Hippel-Lindau (VHL) E3 ligase. The proposed ERE-PROTAC demonstrated effective and reversible degradation of ERα in various breast cancer cells by targeting the DBD, suggesting its potential to address existing resistance issues caused by LBD mutations.
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :