Reactions of Quinazolines

Reactions of Quinazolines

Quinazoline is a compound made up of two fused six-membered simple aromatic rings-benzene and pyrimidine ring. The properties of the pyrimidine ring were affected by the presence of fused benzene ring. The two nitrogen atoms are not equivalent, and the marked polarization of the 3,4-double bond is reflected in the reactions of quinazoline.

Reacion-1:

The majority of quinazoline derivatives exhibit stability in cold acidic or basic conditions but can undergo ring opening reactions, resulting in the production of O-aminobenzaldehyde, ammonia, and formic acid when subjected to high temperatures.

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Reacion-2:

At room temperature in an acidic medium, it is easy to oxidize a quinazoline derivative, resulting in the formation of 3,4-dihydro-4-oxo quinazoline.

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Reacion-3:

In an alkaline medium, potassium permanganate can readily oxidize quinazoline derivatives to yield 3,4-dihydro-6,4-oxo quinazoline.

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See also:

References:

[1]Armarego W L F. Quinazolines[J]. Advances in Heterocyclic Chemistry, 1979, 24: 1-62.

[2]Armarego W L F. Quinazolines[J]. Advances in Heterocyclic Chemistry, 1963, 1: 253-309.