Glycoprotein VI (GPVI) is a member of the platelet membrane glycoprotein family, primarily consisting of an immunoglobulin-like domain. GPVI is mainly located on the surface of platelets and is involved in platelet activation and the clotting process. By recognizing collagen and other ligands, GPVI activates downstream signaling pathways such as Syk and PLCγ2, promoting the release of calcium ions, morphological changes, and aggregation of platelets. The expression of GPVI in platelets is specific, and mutations or dysregulation in its gene expression are associated with the occurrence and development of hemorrhagic and thrombotic diseases.